Lancaster County, Pennsylvania, has been the epicenter of the nation's worst measles outbreak in 35 years. Low vaccination rates among Amish and …

Pennsylvania health officials are offering free measles vaccinations at pop-up clinics across communities. While the outbreak may have peaked, offici…

The suspect in an arson attack on Pennsylvania Governor Josh Shapiro's residence has been charged with attempted homicide, terrorism, aggravated …

A medevac plane crashed soon after takeoff in Philadelphia, killing a child and five others on board as well as one person on the ground.

Donald Trump reclaimed Pennsylvania by improving his margins across the state, shaving Democratic President Joe Biden’s 2020 win in Philadelphia.

Authorities say four of five family members found dead in a house fire near Philadelphia were fatally shot by an adult male relative who also killed …

Authorities were searching the charred remains of a suburban Philadelphia home Thursday, a day after a shootout and fire left two police officers wou…

A federal jury voted to sentence Robert Bowers to death for killing 11 worshippers at Pittsburgh's Tree of Life synagogue in 2018, the deadliest …

Interstate 95 reopened Friday less than two weeks after a deadly collapse in Philadelphia, a quicker-than-expected rebuild to get traffic flowing aga…

AP | The Philadelphia Inquirer says a weekend cyberattack caused the biggest disruption to its operations in 27 years and prevented it from publishin…

Philadelphia is the first major U.S. city to go back to requiring masks indoors since cases declined at the beginning of the year.

At least 3 people were killed in a collision involving more than 50 vehicles on Interstate 81 in Pennsylvania Monday. The crash occurred in the north…

City and federal investigators are working to determine the cause of a fire that tore through a Philadelphia rowhome on Wednesday, killing 12 people,…

At least 13 people, including seven children, were killed following a deadly fire in a Philadelphia apartment building after smoke detectors failed t…

The bodies of ten native American children who were buried on the grounds of what was once the Carlisle Indian Industrial School in Carlisle, Pennsyl…

The U.S. Supreme Court on Wednesday ruled in favor of a Pennsylvania teenager who sued after a profane social media post got her banished from her hi…

Behind the counter of Skippack Pharmacy in Schwenksville, near Philadelphia, owner Mayank Amin has been working late into the night since his indepen…

The family of a Philadelphia Black man shot dead by police appealed for calm as a second night of protests over his death brought renewed violence, w…

First lady Melania Trump made a solo appearance in southern Pennsylvania, where she accused Joe Biden of having a "socialist agenda," and s…

A U.S. federal judge on Monday ruled some of Pennsylvania Governor Tom Wolf's orders to control the coronavirus outbreak unconstitutional, includ…